Three-dimensional imaging in medicine; Lungs--Cancer--Diagnosis
Many lung diseases or injuries can cause biomechanical or material property changes that can alter
lung function. While the mechanical changes associated with the change of the material properties
originate at a regional level, they remain largely...
Cancer is the second-most leading cause of death in the United States, with 1.66 million new cases expected to be diagnosed and over 580,000 Americans expected to die of cancer in 2013 alone. (American Cancer Society 2013) Current treatments result...
Alcoholic liver disease (ALD) ranks among the major causes of morbidity and mortality in the world and effects millions of patients each year. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which progresses...
Premenopausal women have fewer and less severe strokes when compared to postmenopausal females and aged matched males. The most obvious factor that could account for the observed difference is the physiological activity of Estrogen. Numerous...
The properties of gold nanoparticles (GNP) holds promising potential for drug delivery, diagnostics, plasmonic photothermal therapy of diseases, electronics, catalysis, and photovoltaics (Liu et al., 2006; Huang et al., 2003; Thompson, 2007;...
An increasing amount of healthcare resources is used for the treatment and prevention of contractures in patients with spinal cord injury (SCI), with stretch and passive movements remaining the most prominent intervention methods. The results of...
The leading cause of death in the United States is cardiovascular disease, a result of atherosclerosis. The reducing agent N-(2-Mercaptopropionyl)glycine (MPG) as been found to be an effective antioxidant therapy in a number of conditions, and our...
Knee--Mechanical properties; Knee--Pathophysiology; Gait in humans; Osteoarthritis
Osteoarthritis (OA) of the knee is associated with decline in functional capacity and ultimately leads to Total Knee Arthroplasty (TKA) in many of these patients. Exercise regimens prior to surgery may potentially enhance pre and post TKA...
Aortic Valve Bypass surgery has found renewed interest to researchers due to its application in high-risk patients with severe aortic stenosis. This therapy consists of construction of a conduit containing a bioprosthetic or mechanical valve from...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
Persons living with chronic pain encounter a host of physical and psychosocial problems resulting in a loss of quality of life and increased disability. The construct of avoidance has been proposed as a mechanism by which these changes in...
Spinal cord--Wounds and injuries--Complications; Respiratory organs
Pulmonary complications associated with persistent respiratory muscle weakness and paralyses are critical problems faced by patients with chronic spinal cord injury (SCI). The aim of this dissertation is to investigate the role of neurological...
Existing treatment programs and procedures are incapable of addressing the complications encountered with patients who experience spasticity and hypertonia related joint contractures. Current passive therapy procedures and devices are only capable...
Corpus callosum; Diagnostic imaging; Autism--Diagnosis
Early detection of human disease in today’s society can have an enormous impact
on the severity of the disease that is manifested. Disease such as Autism and Dyslexia,
which have no current cure or proven mechanism as to how they develop, can...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
The purpose of this dissertation was to demonstrate that a new method of direct intracellular energy delivery was effective in maintaining viability of in vitro Human Umbilical Vein Endothelial Cells (HUVECs) when exposed to chemical ischemia for...
Pancreatic adenocarcinoma is the fourth leading cause of cancer death in the United States. It is identified by its rapid, invasive progression with a profound resistance to treatments such as chemotherapy. Unfortunately, there is a lack of...
Decorative shield with a torch on either side. At the top is an insignia featuring a ship with sails. In a circle around the insignia are the words "The Handcraft Shops Founded 1904." On the scrolls below the insignia is the phrase...
Buildings; University of Louisville--Buildings; Educational facilities; Gardiner Hall (Louisville, Ky.)
Gardiner Hall seen from an elevated perspective. Current uses: A&S Advising Center; A&S Dean's Offices; A&S Women's and Gender Studies; Family Therapy; A&S Liberal Studies; IT. Named in honor of Clarence R. Gardiner, real estate...
Buildings; University of Louisville--Buildings; Research facilities; Health care facilities;
Entrance to the Child Psychiatry Research Center, University of Louisville, apparently before the facility was named in honor of William Keller, chair of the U of L Department of Psychiatry, in 1978. Location: 608 South Jackson. Current uses:...
