The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
We aimed to examine differences in treatment impacts and quality of life between adult orthodontic patients with Invisalign and fixed appliances. Adults represent a burgeoning branch of orthodontics yet many prospective patients have been reluctant...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
Spinal cord--Wounds and injuries; Stretch (Physiology)
An increasing amount of healthcare resources is used for the treatment and prevention of contractures in patients with spinal cord injury (SCI), with stretch and passive movements remaining the most prominent intervention methods. The results of...
An investigation was made into the relative costs of excavation retention by two systems: conventional soldier pile-wale-tieback support, and support by soil nailing. The investigation included design of excavation supports by the two...
Recent advances in understanding the molecular mechanisms of mutagenesis indicate that most mutations are dependent on the activity of translesion synthesis DNA polymerases. The impact of reducing the level of these polymerases on mutagenesis and...
Background . Heart failure treatment guidelines emphasize the importance of daily weight monitoring. To support this practice, the Health Care Financing Administration Heart Failure Demonstration Project (2000) was designed to evaluate the effect...
Supervisory control systems--Security measures; Automatic data collection systems--Security measures
This thesis describes the development of a prototype security hardened field device (such as a remote terminal unit) based on commodity hardware and implementing a previously developed security architecture. This security architecture has not been...
Electronic commerce--Corrupt practices--Prevention; Internet advertising--Corrupt practices; Internet fraud
Online search advertising is currently the greatest source of revenue for many Internet giants such as Google™, Yahoo!™, and Bing™. The increased number of specialized websites and modern profiling techniques have all contributed to an...
Nanoparticles; Drug delivery devices; Gene therapy
The properties and broad applications of nano-magnetic colloids have generated much interest in recent years. Specially, Fe304 nanoparticles have attracted a great deal of attention since their magnetic properties can be used for hyperthermia...
The acetogenin annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina tri/oba...
Vicinal dithioethers and alkenyl thioethers were synthesized under environmentally
friendly conditions using alkyne and thiol in water. Alkynes were also used to develop a
multibond-fonning reaction that fonned cyclic ketones or ketoesters through...
Israel--Social conditions; Israel--Social life and customs
Times Square went mad with noise and excitement,
and a small freighter slipped from its Brooklyn berth into
the drama of the night. It was December 31, 1949--midnight-January
1, 1950; and I was on my way to the world in general
and Israel and the...
Reformation--England; Henry VIII, King of England, 1491-1547; Monasticism and religious orders--England--History
This thesis is a critical examination of the dissolution of the monasteries under the reign of Henry VIII, and the key role the dissolution played in his plan for the Reformation in England. In addition, the present study found that by closely...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
Law and legislation--Kentucky; Constitutions--Kentucky
Kentucky's third constitution, ratified by voters in 1850 is important historically as the first state charter for which complete record of the convention that drafted it was published, making it possible to research the intentions of the framers....
Simmons University (Louisville, Ky.); African American universities and colleges; African Americans--Education (Higher); Education
Includes names of faculty and students, information about the university and its courses, and images of the Girls' Dormitory and Domestic Science Class. The university has gone by many names since its founding in 1879: The Kentucky Normal and...
Simmons University (Louisville, Ky.); African American universities and colleges; African Americans--Education (Higher); Education
Includes names of faculty and students, information about the university and its courses, and photos of campus buildings and faculty. The university has gone by many names since its founding in 1879: The Kentucky Normal and Theological Institute...
Due to of the rise in numbers of persons experiencing homelessness, communities are working to restrict access that homeless individuals have to public spaces. Many cities across the nation have criminalized aspects of homelessness in attempts to...
Mogul Empire--Social life and customs; Drinking of alcoholic beverages--India--History; Drug abuse--India
Intoxicant use in Mughal India was not only widespread, it also represented an important part of the empire's history and culture. The influence of intoxicants - specifically opium and alcohol - has often been overlooked in secondary literature,...
