The acetogenin annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina tri/oba...
Coronary heart disease--Treatment--Cost effectiveness; Angioplasty; Medical laws and legislation--Kentucky
A myocardial infarction (MI) occurs when blood supply to the heart is cut off by a blockage in one of the coronary arteries. Most hospitals treat a patient with thrombolysis or a percutaneous coronary intervention (PC I). The latter has been...
Sleep disorders in children; Children--Sleep; Blind children
Research has confirmed that individuals with blindness have an increased risk of
developing sleep problems; this is especially problematic for families with young
children who are blind. Not only does the lack of sleep impact the growth...
Few previous studies have compared microbial communities in subterranean and surface environments. Chemical analyses used to characterize the surface and cave microbial environments indicated limited exchange between surface and subsurface waters....
Human exposure to mercury has been shown to cause a number of adverse health outcomes, predominantly neurological effects. The developing fetus is most susceptible, and even low levels of exposure have been shown to produce nervous system deficits....
Trachea--Intubation; Optical fibers in medicine; Clinical medicine--Study and teaching--Simulation methods; Medicine--Study and teaching--Simulation methods
Fiberoptic intubation skills (FOI) are critical in reducing the anesthesia related morbidity and mortality in clinical settings. The purpose of the study was to prove that the simulator can train a novice to achieve the expert level in a relatively...
Critical thinking--Study and teaching (Higher); Critical thinking--Ability testing; Social work education
This study utilized the standardized California Critical Thinking Skills Test (CCTST) Form 2000 to measure students' pretest and post test critical thinking abilities prior to and upon completion of a critical thinking infused curriculum. In...
Modular hip implants are currently being used in total hip arthroplasty revision procedures because it is common to have little or no bone left in the proximal region of the femur and it is difficult to accurately size implants based off of...
Alcohol; Distillation; Alcoholic beverages; Corn--Utilization; Whiskey industry
In the whisky industry there is a balance between the desire to adhere to the traditional production process and the desire to increase profit margins. One solution that follows both stipulations is to increase the alcohol yield of a given batch of...
Green tea--Health aspects; Green tea--Therapeutic use; Polyphenols--Physiological effect; Drug delivery systems; Lungs--Cancer--Treatment
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered...
Accelerated life testing; Reliability (Engineering); Service life (Engineering)
This dissertation is focused on finding lower confidence limits for the reliability of systems consisting of Wei bull components when the reliability demonstration testing (RDT) is conducted with zero failures. The usual methods for the parameter...
Introduction: Osteoarthritis (OA) is a clinical condition affecting over 27 million Americans. There is no known cure for OA other than replacing the diseased joint with a joint prosthesis, total knee arthroplasty (TKA). Purpose: This study...
Bioinformatics; Breast--Cancer--Treatment; Medical care--Data processing
Statistical models have been the first choice for comparative effectiveness in clinical research. Though effective, these models are limited when the data to be analyzed do not fit the assumed distributions; which is mostly the case when the study...
A combination of three techniques – high resolution micro computed tomography (micro CT) scanning, Archimedes-based volume fraction measurement and serial sectioning or milling – were used to determine the volume fraction, trabecular thickness,...
Psychiatry and religion; Mental illness--Social aspects; Mental health services--Social aspects; Protestants--Attitudes
Researchers have long been interested in the relationship among the separate fields of psychology and religion. This dissertation seeks to explore the differences in the way protestant Christians with various religious orientations view mental...
Enterprise zones--Kentucky--Louisville; Enterprise zones--Law and legislation; Regional planning--Kentucky--Louisville; Economic policy--Kentucky--Louisville
Multiple analytic methods are used to provide an
analysis and evaluation of specific economic and neighborhood
development policies undertaken by and continued by the
Commonwealth of Kentucky, the City of Louisville, and
Jefferson County since the...
Six sigma (Quality control standard); Manufacturing processes--Quality control--Statistical methods
The objective of this thesis was to apply what was learned from Six Sigma while working for General Electric, towards real applications to improve processes. Two manufacturing problems were targeted. One of the issues dealt with variation, in an...
The purpose of this study was to investigate how various components of family literacy programs such as operational characteristics (enrollment procedure, hours of operation, time of class, curriculum selection, type of instruction, and age of...
Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is known to confer antioxidant protection in vivo. Rather than directly reacting with free radicals, however, SFN works by inducing Nrf2, a transcription factor that binds to...
In 2003, Wilson Creek running through Bernheim Arboretum and Research Forest in central Kentucky was restored to its original winding path through a valley field. Early 20th century settlers had previously redirected this creek to run a straight...
