Human adenoviruses (Ads) can infect and replicate in cells at different cell-cycle stages. Ads with the E1 B55K deletion preferentially replicate in cancer cells and cause oncolysis. Our laboratory has previously shown that the Ad E1 b gene is...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
Mosquitoes as carriers of disease; Dengue viruses; Mosquitoes--Physiology
In the course of their life cycle, mosquitoes undergo an ontogenetic niche shift; immature larval development occurs within an aquatic habitat from which adult mosquitoes subsequently disperse into the terrestrial environment. While adult female...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
Colon (Anatomy)--Cancer--Genetic aspects; Cancer cells--Mathematical models
Research over the past twenty five years has led to the development of the hypothesis that colorectal cancer is caused by the accumulation of mutations in tumor suppressor genes and proto-oncogenes. The last ten years has also revealed that the...
Hepatitis C virus--Research; Interferon--Therapeutic use; Adenosylmethionine
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease in the United States and is a huge burden on the US healthcare system. The FDA-approved traditional standard of care for HCV is pegylated interferon-alpha (lFNα) combined...
Respiratory syncytial virus is the leading cause of lower respiratory tract infection
in infants and currently lacks an effective vaccine or treatment beyond symptom relief.
The atomic force microscope is particularly well suited for imaging...
HIV-positive persons--Employment; HIV-positive persons--Mental health; AIDS (Disease)--Patients--Mental health; AIDS (Disease)--Patients-- Employment
It is well established that HIV (human immunodeficiency virus), the virus responsible for AIDS, directly attacks the central nervous system, altering cognition, behavior, and affect, and can result in a full dementia syndrome. HIV-associated...
Among gynecological malignancies, carcinoma of the cervix is the leading cancer type worldwide. Conversely, vaginal tumors account for an incidence of approximately 1-2% of lower genital tract malignancies. Interestingly, the major shared risk...
Parkinson's disease--Treatment; Stem cells--Therapeutic use
Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the
progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and
the resulting imbalance between dopamine and acetylcholine in the basal ganglia...
It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Nanoparticles; Drug delivery devices; Gene therapy
The properties and broad applications of nano-magnetic colloids have generated much interest in recent years. Specially, Fe304 nanoparticles have attracted a great deal of attention since their magnetic properties can be used for hyperthermia...
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Despite the development of various strategies to treat cancer, it remains one of the most deadly diseases worldwide due to the limited effects...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
Depression is one of the most frequent causes of disability worldwide. It can
affect the psychological, social, and physical wellbeing of those that suffer from it, the
majority of which are women. Depression has been linked to immune activation as...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
Complement, an early recognition system of innate immunity that senses local tissue damage and infection, cross-talks with and regulates other signaling systems, including Toll-like receptor (TLR) pathways. In the context of periodontitis,...
Prostate--Cancer--Diagnosis; Chemical detectors; Biosensors
Prostate cancer is the most common type diagnosed among men in the United States.
Random oligodeoxynucleotide (ODN) libraries are used to generate DNA aptamers by
systematic evolution of ligands by exponential enrichment (SELEX). We explored...
The revolution in information technology and the explosion in the use of computing devices in people's everyday activities has forever changed the perspective of the data mining and machine learning fields. The enormous amounts of easily...
